Used to hunt bears in Montana, Alaska and Oregon. Lived in Alaska about two years and never saw a bear out hunting up there. Lived here in Oregon most my life and I haven't seem two bears since coming back from Montana. In Montana seeing them was almost a daily occurrence! If I wanted to go hunt...
Only ever used loctite on one scope and to get them off to put on a new scope I had to take the gun to a gunsmith! That's when I found out not to use red locktite! fact is after that I have never used locktite at all and no problems!
If I could afford to hunt a moose, I can't, I'd take one of two rifles and loads. either my 30-06 with 180gr Hornady SP's or my 6.5x55 with 140gr Speer HC's. Well maybe. Just got my 260 put together and really liking it with 140gr Speer HC's. Primary going in would be the 30-06!
For big game my though is the 6,5 blows any 6mm out of the water with better selection of bullet's. My 6.5x06 is on a 700 Rem Action and magazine is long enough I had it chambered so I could seat the 140gr bullet to the junction of the neck and shoulder.
Years ago I shot a 7mm Rem Mag and found the best bullet for me was the 160gr Speer HC. Heavier bullet's upped the recoil to much and didn't do a lot more. Lighter bullet's got torn up with the velocity. Had a 760 in 280 at the time but never fooled with it a lot, I much prefer bolt action guns...
I'd never hunted anything with a 30-06 till maybe 6 or 7 years ago. have a really nice custom I inherited from a close friend and worried about banging it up. Shoot he'd never used it since I'd known him either. 1903 Springfield by Paul Jaeger. My friend had it made as his get out of the service...
I have killed three elk one shot each with my 6.5x06 and 140gr HORNADY SP. Wouldn't phase me to use the 140gr Speer HC either. Mater of fact have it loaded in my 6.5x55 and 260 Rem. I believe that what bullet you use is no where near important as how you use the bullet you you have.