I can't speak for the guide, but I did recently bite the bullet and ordered a pair of the Zamberlan KUIU Pamir GTX RR boots and absolutely love them. When I received them I had a little bit of a fit issue but put in a pair of Merino Superfeet insoles and they fit great. Wore them around the house a little, then took them on a 12 mile hike last weekend with no issues and just got done trudging through 11.6 miles of some good snow in the Elkhorns, still no issues.
I don't think you would be disappointed with the guides. I have several friends that tried them this fall and absolutely loved them. I did have one buddy that wasn't to thrilled on the insole fit for his feet, but I told him to try a pair of Superfeet insoles and see what he thinks. Haven't heard if he tried that yet.
Just my 2 cents