I think that the only (2) calibers that it has made sense for me in were 25 cal and 30 cal. The .257 Weatherby Mag is a killer round. I bought a Vanguard Wilderness a while back and have been really, really impressed with the overall accuracy of the rifle/cartridge. Also, it hits hard for what it is. I've been really impressed with the performance on wild hogs with the copper rounds. Having the extended point blank range makes the cartridge really nice on a Pronghorn hunt, too, for example. I do like the 25-06, but there is a marked difference between the two, which justifies the jump in my opinion. Also, ammo is a lot cheaper than it used to be and is available in a majority of stores (sans the wal marts of the world).
The 30 cal is the other caliber that I like the jump in. Being able to get another 200 FPS or so and 4-500 LBS of energy over the win mag makes it attractive given the small increase in recoil. There are a ton of options 30 cals now, so, you can get that performance in other standardized cartridges, but, if I were to do it again, I would have bought a .300 Weatherby rather than the .300 win mag.
Also -- I agree with the above post. While I really enjoy a good ballistics discussion, the reality is that my optimal shooting range as a hunter is within 400 yards. Outside of that is really where the ballistics make a difference, so, my nitpick-y opinions on performance don't matter in the field.