I use LRP in most large calibers. 7 mag, 7 ss, 6.5 max and 7 prc. I find that I don't pressure out as fast and get better ES and SDs with LRP. The only worry would be hunting in extreme cold weather with larger Calibers.
I have shot the Berger 168 out of mine and have taken many animals with it before jumping up to a Berger 180 vld. The 168 was at 2990 FPS and the 180 is 2960 from a 9.25 twist.