EDIT:: sorry I forgot CO won't let you use sabots. I would try the ELD-X or full size Thor, Fury, or no excuses. The Eld-x also shot well for me and seems to be working for others.
I’ll give you a run down on my experience last year. I had my first muzzleloader elk hunt here in Nevada. I...
Shoot, I'm a NV resident and I am looking to go to CA for better opportunity for my kids. Even the Junior hunts are hard to get in most areas here.
https://www.ndow.org/blog/hunt-statistics/ is where the past few years of information is at.
I would say this is the best pros/cons argument. I would do 30-40-50. Then know where you hit from 30 in and you might have more time to dial from 50 out.
I have just found that my re-fletched arrows are not as durable as arrows I bought. I'm going to try some different glue, but I might try the easyvanes from above too. They look interesting.
I don't know how it works for what you have, but we personally know 2 people that have cured their cancer (colon and pancreatic) using ivermectin and naltrexone. There are more and more studies being done. Might be worth it to talk to your Dr. about.